Jigsaw puzzle missing one piece before completion

Finding the missing piece of the puzzle in age-related muscle loss

Despite affecting most people over the age of 50, we don’t really know why age-related muscle loss happens. Dr Katarzyna Goljanek-Whysall, now Senior Lecturer at the National University of Ireland, Galway but who led the work when at the University of Liverpool, thinks that oxidised microRNAs could be an important clue to unlocking better treatments for declining muscle function as we get older.

Collection of blue and purple cells

Understanding the science behind Sjögren’s Syndrome

Sjögren’s syndrome is a disease where the immune system attacks healthy cells in the glands, leading to dry eyes and mouth but can affect other parts of the body such as joints, lungs, skin and nervous system. Although we can ease the symptoms, we don’t have any good treatments. Dr Elizabeth Jury, Dr Coziana Ciurtin and Lucia Martin-Gutierrez, with their team at UCL, looked at the blood of patients and found their immune systems behaved in two different ways. Identifying these two groups will help us treat this uncomfortable disease.

Walking shoe standing on the ground

New steps to recovery for painful walking in older people

Supervised walking exercise is used to treat leg pain in older people caused by restricted blood flow. But it’s expensive for the NHS to provide and often difficult for patients to complete. Professor Lindsay Bearne and her team trained physiotherapists to provide patients with the knowledge, motivation and skills they needed to engage with walking exercise in their own time outside of a medical facility.

Multiple spherical light bulbs viewed looking up

Long-lived naked mole-rats are helping us understand healthy ageing

To understand how brains age, researchers often study short-lived rats and mice. Another rodent, the naked mole rat, lives for decades and ages healthily. Professor Ewan St. John Smith and his team are examining this unusual animal to see whether its unique ageing biology can unlock new ways to treat and cure neurodegenerative diseases.

Photo of human left hand in stream of light

Spotting dementia earlier in the deaf community using an automated screening tool

Within the older British Sign Language community, dementia can show itself as changes in the way someone signs – but these subtle changes are hard to spot by those who don’t use sign language. Dr Anastasia Angelopoulou and her team have developed an automated machine learning tool that can spot these changes. The tool will help identify the early stages of dementia among older users of sign language – ensuring they get the right support quicker.

Close-up photo of walnuts on a dark background

Can ‘brain training’ pass the test? Exploring whether people with dementia can brain train at home

Brain training is a fun and simple intervention to keep minds active in older age. However, there are many unknowns. What benefits does it have on the brain? And can people living with dementia realistically brain train using technology they’re not necessarily familiar with? Dr Lucy Beishon wanted to find out whether people living with dementia can do brain training at home using a computer, and to see if it has potential to bring benefits.

Mid & East Antrim Agewell Partnership lead image

IMPACTAgewell® – Revolutionising the way that older people access healthcare

Older people may need support from a variety of health and social care providers. The IMPACTAgewell® project brings together a range of different providers to create a holistic model of care. They support older people to understand and navigate the health and social care services that they need, empowering them to take control.

Red and white roses climbing up a graffitied concrete wall

What does ‘good care’ look like? Understanding the complex systems in care homes

Change is a common and necessary part of care environments – but what sort of culture within care homes leads to them adapting well to change? Dr Al Ross and his team wanted to understand what ‘good care’ looks like, discover which aspects of care homes’ systems and culture support this, and share their findings to improve life for older people in care homes.